OK, there's a lot to unpack here. Let me try to tackle this for you.
Natural vs. synthetic vs. enhanced: Natural, for sure. No question. The other two retain approximately zero value. Natural diamonds actually do pretty well for this, IF you buy them right! In other words, if you go to Tiffany, you'll lose a lot of money in the future, because your cost basis was all wrong to begin with. But if you buy well, you can expect to hold value, and eventually increase it (if you look long term). Remember, unlike many other things you can buy, a diamond really will last your whole life and become a part of your estate plan one day.
We can debate the intrinsic value of diamonds all day long, but there's really no point. Human beings have agreed on the convention that real diamonds are worth money, and that convention has held for thousands of years. There's no reason to believe that will change any time soon.
4 Cs:
Cut: Focus on a GIA XXX cut. At this price point, there's no reason to go with any of the secondary labs. Get a GIA. And don't worry about "super, ultra, mega, extra" ideal cuts. They're really not a thing. GIA is widely considered the highest authority in diamond grading, so if they give it their seal of approval, you can relax and consider the job done. There are many others claiming their standards are better, higher, tighter than GIAs... And maybe they are. But there is a point of diminishing returns here, and it's not worth paying 30% more for ULTRA CUT that's maybe 0.2% more light return.
Color: This is really subjective. Some people are very sensitive to color, some aren't. My best advice is to go look at some stones, and see how low you can go before it starts to look dark to you. As a rule of thumb, one color grade costs about 15%, so bear in mind that jumping from an H to an E (for example) will be a 50% price increase or so.
Clarity: This is where you can save some money! VS1 is overkill for almost anyone. As long as a diamond is clean enough that no inclusions are visible to your naked eye, then by definition the inclusions aren't disrupting the flow of light, so who cares? Look at VS2 or SI1 and save big.
I'm not sure if this answers everything - feel free to ask any followup questions!
Have you actually looked at any stones in real life? I think it might really help you.
Where are you located?